science & platforms
The Frontier™ Platform
Proprietary platform powered by chemoproteomics, covalent chemistry, and machine learning
Chemoproteomics is an approach to understand the interaction between small molecules and proteins in cellular contexts.
Frontier uses a chemoproteomics platform paired with machine learning algorithms to discover binding pockets (or druggable hotspots) within proteins involved in critical disease pathways, then targets them pharmacologically. Frontier’s proprietary drug discovery capabilities have been built to accelerate the discovery and development of precision medicines. Our platform integrates a set of leading proteomic capabilities, generating billions of data points stored within our proprietary hotspot database, with a data-driven and evolving covalent fragment library. Insights from proteome screening in disease relevant systems are combined with those from cutting edge mass spectrometry, machine-learning algorithms, modeling, simulation, and structural information, alongside innovative medicinal chemistry.
Understanding Frontier’s Technology
Machine Learning / Artificial Intelligence
Frontier has developed machine learning algorithms that leverage our unique hotspot data to classify, for a given protein, the relative reactivities and the binding potential of specific regions. This enables not only the prioritization of particular targets directly from our database, but also the design of effective screening strategies.