Sr. Scientist/Principal Scientist Chemical Biology - Boston

About Frontier Medicines

Frontier Medicines, located in South San Francisco, CA and Boston, MA, is a precision medicine company that has pioneered a powerful discovery and development platform designed to generate medicines against disease-causing proteins previously considered undruggable. We are deploying our technologies in chemoproteomics, covalent drug discovery, and machine learning to develop a pipeline of groundbreaking medicines against the most important drivers of disease. Frontier has been recognized as a Fierce 15 company and a C&EN Start-Up to Watch. Our lead program targets both the active and inactive forms of KRASG12C, a validated driver in a number of cancers that until recently have been undruggable. Our pipeline embodies our vision of boldly advancing science to defeat disease, starting with cancer.

About the Role

Frontier Medicines is seeking a highly motivated individual to fill the position of Senior/Principal Scientist in the Chemical Biology team. The successful candidate is expected to have an excellent working knowledge of high-throughput screening and cellular pharmacology techniques, ideally with experience in protein degraders or other loss of target protein applications. This position requires working as part of a multidisciplinary team in a fast-paced drug-hunting environment.

Frontier Medicines offers a dynamic environment with the opportunity to impact the lives of patients while conducting cutting-edge science.  There are short communication lines across the company, and we encourage and support the professional development of our team members.

Key Responsibilities
  • Lead a small team focused on cell-based screening for novel protein degraders
  • Conduct secondary screening for loss of signal MoA determination
  • Conduct high-throughput cellular target engagement assays for lead optimization
  • Creation of cell lines containing mutant or tagged forms of proteins on various promoters (e.g., native and dox-inducible)
  • Experience partnering with CROs to increase capacity and capabilities
  • Mentorship and professional development of junior colleagues


  • Ph.D. in biological science (biochemistry, molecular biology, cellular biology, or related discipline). 
  • Experience with automation and liquid handling devices, e.g., Echo, MultiFlo
  • Experience in degrader target validation techniques such as dTAG and siRNA.
  • Excellent communication, organization, and technical writing skills. 
  • Strong problem-solving skills, ability to learn new skills. 
  • Legally authorized to work in the U.S.


To apply, please send your resume to