Associate Director / Director, Disease Biology - Boston

About Frontier Medicines

Frontier Medicines, located in South San Francisco, CA and Boston, MA, is a precision medicine company that has pioneered a powerful discovery and development platform designed to generate medicines against disease-causing proteins previously considered undruggable. We are deploying our technologies in chemoproteomics, covalent drug discovery, and machine learning to develop a pipeline of groundbreaking medicines against the most important drivers of disease. Frontier has been recognized as a Fierce 15 company and a C&EN Start-Up to Watch. Our lead program targets both the active and inactive forms of KRASG12C, a validated driver in a number of cancers that until recently has been undruggable. Our pipeline embodies our vision of boldly advancing science to defeat disease, starting with cancer.

About the Role

Frontier Medicines is seeking a highly motivated individual to fill the position of Assoc. Director/Director, Disease Biology in our Disease biology team that is focused on target validation, drug mechanism of action and resistance, cancer biology, pharmacology and biomarker discovery. The successful candidate will be part of a team that enables the drug discovery project pipeline delivering strategy and key data to drive new ideas into clinical development. The team is focused on the discovery of new medicines to treat cancers and other serious disorders. The position will report to the Senior Director of Disease Biology and will be located in Boston.

The Assoc. Director/Director, Disease Biology is a key contributor to Frontier Medicines’ success and will be interacting with senior leaders routinely. This is an opportunity to join and work in a highly collaborative and energetic team in a startup environment with short communication lines and quick decision making across functions and departments.

Key Responsibilities
  • To lead the Boston disease biology team and coordinate their activities across the drug discovery pipeline.
  • To design, execute, and analyze key biological experimental strategies to tackle previously undruggable drivers of disease and enable clinical development strategies, with a high level of independence and creativity.
  • Contribute to and lead project teams focused on target selection, target validation, lead generation and lead optimization to enable delivery of novel drug candidates into clinical development.  
  • Contribute to the design and build out of disease biology strategy and platform technologies.
  • Establish and lead collaborations with leaders in the oncology community.
  • Effectively communicate with colleagues and stakeholders; create and present research updates and provide strategic input to team/company meetings; enable presentation and publication of novel discoveries.
  • Responsible for the group maintaining clear, detailed laboratory notebooks to document all experiments and findings.
  • Comply with best laboratory safety practices.
Qualifications
  • Ph.D. or M.D./Ph.D. in a biological or chemical science (biochemistry, biophysics, cellular biology, bioengineering, or related discipline), with at least 10 years of relevant post-graduate experience that includes experience in the biotech or pharma sectors.
  • Deep scientific and technical expertise in assay development and drug discovery.
  • Experience in oncology drug discovery and protein degrader technologies.
  • Experience supervising and direct reports and managing multifunction teams.
  • Successful track record of publications in high-impact, peer-reviewed journals and presentations at relevant research meetings
  • Excellent communication, organization, and technical writing skills.
  • Strong problem-solving skills, ability to learn new skills.
  • Ability to work with independence and drive in a startup environment.
  • A commitment to excellence, including ensuring that fellow team members focus on high quality science and a professional working environment.
  • Legally authorized to work in the US.

To apply, please send your resume to careers@frontiermeds.com.